INFLAMMATION AND INFECTIOUS DISEASE
Noscapine Analogs and Methods Related Thereto
Inventor: Ritu Aneja
IP status: Patent pending
GSU case no.: 2010-13
There is an ongoing need to identify therapeutic methods to treat inflammation, especially those induced by auto-immune diseases. Microtubule disrupting agents are an emerging class of antiinflammatory agents. Current therapies involving microtubule-targeting drugs cause unwanted side effects. A novel class of Noscapine analogs has been discovered, which function by modulating microtubules without causing the severe side effects of presently used drugs.
Georgia State and Emory University inventors have conceived, designed and synthesized brominated Noscapine analogs, showing potent anti-inflammatory activity in septic and sterile inflammation models. These compounds do not affect cellular viability and function in a dose-dependent and time-dependent manner. One major advantage is that these Noscapinoids modulate microtubule dynamics by increasing the “pause-time” and do not affect the overall microtubule existence. The mechanism possibly involves inhibition of TNF-a, IL-8 and nitric oxide release.
Chester A. Bisbee
Associate Vice President and Director
Office of Technology Licensing and Commercialization
217 Dalberg Hall
- Treatment and prevention of inflammatory diseases, such as Alzheimer’s, arthritis, asthma, atherosclerosis, Crohn’s disease, colitis, dermatitis, Hepatitis, irritable bowel syndrome and inflammatory bowel disease, among others
- Treatment and prevention of abnormal cellular proliferation, such as eczema, psoriasis, atherosclerosis, arthritis, osteoporosis, leukemia, malignant tumors, etc.
- Overcomes the microtubule over-polymerization and de-polymerization effects caused by taxanes and Vincas, preventing side effects like GI toxicity, neuropathies and immunosuppression
- Subtle attenuation of microtubule dynamics. Do not alter monomer/polymer ratio leading to nontoxicity
- Displays anti-inflammatory activity without affecting cell viability
- Induce autophagy thereby dampening inflammation