Chemosensors for Hydrogen Sulfide
Patent Status: Patent Pending
GSU case no 2011-06
Hydrogen sulfide is a well-known toxic gas and an important neuromodulator for numerous neural functions. It is also produced endogenously in the CNS and is recognized as an important gaseous signaling molecule. It is known for its regulatory/modulatory roles in the CNS and cardiovascular,
respiratory, gastrointestinal and endocrine systems. There is a strong need for rapid and selective detection agents for H2S quantification in industrial, health/medical and research settings.
Georgia State University researchers have developed a chemosensor-based hydrogen sulfide probe usable in aqueous buffer and biological samples (serum, whole blood, etc.). This probe allows for fast (within seconds), selective and quantitative detection of hydrogen sulfide. This novel chemosensor is an organic/organometallic small molecule (or a macromolecule) comprising a fluorophore and reactive functional group(s). The probe elicits a linear concentration-signal relationship at biological H2S concentrations.
Chester A. Bisbee
Associate Vice President and Director
Office of Technology Licensing and Commercialization
217 Dalberg Hall
- Analyzing H2S in gas/liquid streams in solution based or immobilized assays
- Analyzing liquid and gaseous effluents from various industries
- H2S detection in water samples for quality and safety
- In research labs for conducting in vitro bioassays for H2S detection in samples such as blood serum, etc.
- Low detection limits (up to <10 µM), biological/aqueous compatibility and short equilibration time
- Easy-to-use, one-step procedure. No additional reagents required other than the chemosensing reagent
- Performed under mild and simple conditions, time efficient
- No sophisticated instruments required